RNA Modifications Meet Tumors
Zhiyuan Yang, Siyu Zhang, Tian Xia, Yue Fan, Ying Shan, Kaiwen Zhang, Jiayan Xiong, Miao Gu, Bo You
Abstract
Abstract: RNA modifications occur through the whole process of gene expression regulation, including transcription, translation, and post-translational processes. They are closely associated with gene expression, RNA stability, and cell cycle. RNA modifications in tumor cells play a vital role in tumor development and metastasis, changes in the tumor microenvironment, drug resistance in tumors, construction of tumor cell-cell “internet”, etc. Several types of RNA modifications have been identified to date and have various effects on the biological characteristics of different tumors. In this review, we discussed the function of RNA modifications, including N 6 -methyladenine (m 6 A), 5-methylcytosine (m 5 C), N 7 -methyladenosine (m 7 G), N 1 -methyladenosine (m 1 A), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I), in the microenvironment and therapy of solid and liquid tumors. Keywords: tumor, RNA modification, non-coding RNA, tumor microenvironment, tumor therapy