<i>In Vitro</i> Potency and Spectrum of the Novel Polymyxin MRX-8 Tested against Clinical Isolates of Gram-Negative Bacteria
Leonard R Duncan, Wen Wang, Hélio S. Sader
Abstract
isolates not intrinsically resistant to colistin and 0.5 and 1 mg/L, respectively, against both the A. baumannii and P. aeruginosa isolate sets. All three polymyxin-class compounds retained activity against meropenem-resistant and multidrug-resistant isolate subsets but were inactive against isolates displaying acquired or intrinsic resistance to polymyxins. These results support the continued development of MRX-8 to treat serious Gram-negative infections.
Topics & Concepts
PotencyGramGram-negative bacteriaMicrobiologyIn vitroBacteriaPolymyxinGram-positive bacteriaPolymyxin BBiologyAntibioticsBiochemistryEscherichia coliGeneticsGeneAntibiotic Resistance in BacteriaTuberculosis Research and EpidemiologyVibrio bacteria research studies