Ultrasmall Mn-doped iron oxide nanoparticles with dual hepatobiliary and renal clearances for <i>T</i><sub>1</sub> MR liver imaging
Sanghoon Lee, Arim Byun, Ju-Hee Jo, Jong‐Min Suh, Jeasang Yoo, Mi Hee Lim, Ji-wook Kim, T. Shin, Jin‐sil Choi
Abstract
Ultrasmall Mn-doped iron oxide nanoparticles (UMIOs) offer sequential blood vessel and liver imaging, optimal T 1 effects, hepatocyte uptake, and dual excretion pathways, improving imaging efficacy and safety compared to conventional agents.
Topics & Concepts
HepatocyteIron oxide nanoparticlesNanoparticleExcretionIron oxideChemistryInternal medicineMedicineMaterials scienceNanotechnologyBiochemistryOrganic chemistryIn vitroMRI in cancer diagnosisNanoparticle-Based Drug DeliveryGenetic and Kidney Cyst Diseases