Synthesis and antiproliferative activity of new chlorin e6 glycoconjugates
Natalia S. Kuzmina, Vasilii F. Otvagin, Lubov V. Krylova, Alexander V. Nyuchev, Yuliya V. Romanenko, О. И. Койфман, Irina V. Balalaeva, Alexey Yu. Fedorov
Abstract
New water soluble conjugates of chlorin e6 derivative–zinc complex with β-d-galactose or β-d-glucose have been synthesized as potential agents for the photodynamic therapy of cancer. They exhibit photoinduced cytotoxicity at low micromolar concentrations with IC50(dark)/IC50(light) ratio of ∼50.
Topics & Concepts
ChemistryChlorinGlycoconjugatePhotodynamic therapyCytotoxicityConjugateIC50Derivative (finance)Combinatorial chemistryZincPhotochemistryBiochemistryOrganic chemistryIn vitroEconomicsMathematical analysisFinancial economicsMathematicsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine ChemistryNanoplatforms for cancer theranostics