Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies
Nisreen M.A. Okba, Ivy Widjaja, Wentao Li, Corine H. GeurtsvanKessel, Elmoubasher Farag, Mohammed Al-Hajri, Wan Beom Park, Myoung‐don Oh, Chantal Reusken, Marion Koopmans, Berend‐Jan Bosch, Bart L. Haagmans
Abstract
We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.
Topics & Concepts
SerologyMiddle East respiratory syndrome coronavirusAntibodyVirologyMiddle East respiratory syndromeRespiratory systemCoronavirusTiterVirusAntibody titerBiologyImmunologyMedicineCoronavirus disease 2019 (COVID-19)PathologyInternal medicineDiseaseInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral gastroenteritis research and epidemiology