Litcius/Paper detail

Cancer immunotherapy: harnessing the immune system to battle cancer

Yiping Yang

2015Journal of Clinical Investigation1,435 citationsDOIOpen Access PDF

Abstract

The recent clinical successes of immune checkpoint blockade and chimeric antigen receptor T cell therapies represent a turning point in cancer immunotherapy. These successes also underscore the importance of understanding basic tumor immunology for successful clinical translation in treating patients with cancer. The Reviews in this Review Series focus on current developments in cancer immunotherapy, highlight recent advances in our understanding of basic aspects of tumor immunology, and suggest how these insights can lead to the development of new immunotherapeutic strategies.

Topics & Concepts

ImmunotherapyCancer immunotherapyChimeric antigen receptorCancerMedicineImmune systemImmunologyImmune checkpointBlockadeReceptorInternal medicineCAR-T cell therapy researchCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses