Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways
Hyeonho Kim, Dong‐Wook Kim, Jinhu Kim, Hee‐Yoon Lee, Dongseok Park, Hyeyeon Kang, Keiko Matsuda, Fredrik Sterky, Michisuke Yuzaki, Jin Young Kim, Se‐Young Choi, Jaewon Ko, Ji Won Um
Abstract
Neuron-specific Clstn3 deletion caused significant reductions in number of excitatory synaptic inputs. Moreover, expression of Clstn3 cadherin domains in CA1 neurons of Clstn3 conditional knockout mice rescued structural deficits in excitatory synapses, especially within the stratum radiatum layer. Collectively, our results suggest that Clstn3 links to SS4-positive Nrxns to induce presynaptic differentiation and orchestrate excitatory synapse development in specific hippocampal neural circuits, including Schaffer collateral afferents.
Topics & Concepts
Schaffer collateralExcitatory postsynaptic potentialNeurosciencePostsynaptic potentialBiologyConditional gene knockoutHippocampal formationSynapseNeurexinExcitatory synapseCell biologyInhibitory postsynaptic potentialReceptorPhenotypeBiochemistryGeneNeuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology ResearchCellular transport and secretion