Generative adversarial network (GAN) model-based design of potent SARS-CoV-2 Mpro inhibitors using the electron density of ligands and 3D binding pockets: insights from molecular docking, dynamics simulation, and MM-GBSA analysis
Annesha Chakraborty, Vignesh Krishnan, Subbiah Thamotharan
Topics & Concepts
Docking (animal)AutoDockMolecular dynamicsChemistryMoleculeDrug discoverySmall moleculeCombinatorial chemistryComputational chemistryComputational biologyBiochemistryBiologyMedicineOrganic chemistryGeneIn silicoNursingComputational Drug Discovery MethodsMachine Learning in Materials ScienceProtein Structure and Dynamics