Synthesis, characterization and antimicrobial activity of transition metal complexes of 4-[(2-hydroxy-4-methoxyphenyl)methyleneamino]-2,4-dihydro-3H-1,2,4-triazole-3-thione
Someshwar Bhale, Ashok Yadav, Pintu G. Pathare, Sunil U. Tekale, Fernanda Paiva Franguelli, László Kótai, Rajendra P. Pawar
Abstract
A novel nitrogen containing 3 H -1, 2, 4-triazole-3-thione-2, 4-dihydro-4-[(2-hydroxy-4-methoxyphenyl) methylene]-amino ligand (H 2 L) was synthesized using an equimolar ratio of 4-amino-1, 2, 4-triazole-3-thione and 2-hydroxy-4-methoxybenzaldehyde. A series of Mn (II), Fe (II), Co (II), Ni (II), Cu (II), Zn (II), Cd (II) transition metal complexes were synthesized using the ligand. The synthesized ligand and transition metal complexes were characterized by using IR, 1 H NMR, 13 C NMR, Mass spectrometry, UV, XRD and TGA investigation methods. Spectral data suggests that the ligand acts as a tridentate SNO donor. Further, the synthesized H 2 L ligand and their metal complexes were screened for antimicrobial activity. The results of biological activities showed that the metal complexes have higher antifungal as well as antibacterial activity as compared to the parent H 2 L ligand against the tested microbes.