VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy
Jennifer Bosco, Zhiwei Zhou, Sofie Gabriëls, Mayank Verma, Nan Liu, Brian K. Miller, Gu Sheng, Dianna Lundberg, Yan Huang, Eilish Brown, Serene Josiah, M. Muthuraman, Matthew J. Traylor, Nancy Chen, Atsushi Asakura, Natalie De Jonge, Christophe Blanchetot, Hans de Haard, Heather S. Duffy, Dennis Keefe
Abstract
mice inhibited the VEGF:Flt-1 interaction, promoted angiogenesis, and improved muscle function. These studies suggest a potential therapeutic benefit of Flt-1 inhibition for patients with Duchenne muscular dystrophy.
Topics & Concepts
Duchenne muscular dystrophyMuscular dystrophyAngiogenesisVascular endothelial growth factorMedicineEndocrinologyInternal medicineDystrophinSkeletal muscleNeovascularizationVasodilationCancer researchPharmacologyVEGF receptorsMuscle Physiology and DisordersAngiogenesis and VEGF in Cancer