Skin microbiota as a therapeutic target for psoriasis treatment: Trends and perspectives
Roberta Balansin Rigon, Andréa Carolina Pinheiro de Freitas, Juliano Lemos Bicas, Karina Cogo, Alberto Keidi Kurebayashi, Renata Ferreira Magalhães, Gislaine Ricci Leonardi
Abstract
Psoriasis is a chronic, immune-mediated disease that has a major negative impact on a patient's quality of life. Although several literature reviews indicate that skin microbiota may play an important role in the development and regulation of the immune and inflammatory response of psoriasis, few clinical studies are demonstrating the benefits of using pre-, pro- and synbiotics as a therapeutic alternative at the management of the disease. In this review, we showed the use of probiotic microorganisms that may contribute to skin homeostasis and compiled the clinical trials that demonstrate the effect of therapy with probiotics on patients with psoriasis, an important area for scientific exploration in dermatology and being the first review article to compile this information.