Circular RNA coiled-coil domain containing 66 regulates malignant development of papillary thyroid carcinoma by upregulating La ribonucleoprotein 1 <i>via</i> the sponge effect on miR-129-5p
Peipei Li, Junhui Chen, Jun Zou, Wei Zhu, Yan Zang, Hongwu Li
Abstract
experiments demonstrated that knockdown of circ-CCDC66 markedly suppressed the proliferative, migratory, and invasive capacities of PTC cells. Mechanistically, miR-129-5p was a target gene of circ-CCDC66 and was downregulated in PTC tissues. LARP1, a downstream target of miR-129-5p, was upregulated in PTC tissues. In addition, we confirmed that inhibition of circ-CCDC66 could repress xenograft tumor growth. Circ-CCDC66 promoted PTC proliferation, migration, invasion, and tumor growth by sponging miR-129-5p and promoting LARP1 expression.
Topics & Concepts
Gene knockdownDownregulation and upregulationCancer researchCircular RNACell growthThyroid carcinomaChemistryMolecular biologyBiologyCell cultureGeneThyroidEndocrinologyGeneticsBiochemistryCircular RNAs in diseasesMicroRNA in disease regulationRNA Research and Splicing