Hypoxia-activated glutamine antagonist prodrug combined with combretastatin A4 nanoparticles for tumor-selective metabolic blockade
Mengfei Zheng, Hang Xu, Yue Huang, Jiali Sun, Honglei Zhang, Zheng Lv, Zhilin Liu, Zhaohui Tang, Xuesi Chen
Topics & Concepts
ProdrugTumor hypoxiaPharmacologyGlutamineChemistryIn vivoHypoxia (environmental)AntagonistCancer researchToxicityMedicineInternal medicineReceptorBiologyBiochemistryRadiation therapyOrganic chemistryAmino acidOxygenBiotechnologyCancer, Hypoxia, and MetabolismNanoplatforms for cancer theranosticsImmune cells in cancer