Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model
Quanchi Chen, Jordi‐Amat Cuello‐Garibo, Ludovic Bretin, Liyan Zhang, Vadde Ramu, Yasmin Aydar, Yevhen Batsiun, Sharon Bronkhorst, Yurii Husiev, Nataliia Beztsinna, Lanpeng Chen, Xue‐Quan Zhou, Claudia Schmidt, Ingo Ott, Martine J. Jager, Albert M. Brouwer, B. Ewa Snaar‐Jagalska, Sylvestre Bonnet
Abstract
showed more modest photoindexes (PI ∼ 9), retro-orbitally administered PACT treatment significantly inhibited growth of the engrafted tumors. Overall, this study represents the first demonstration in zebrafish cancer models of the clinical potential of ruthenium-based PACT, here against conjunctival melanoma.
Topics & Concepts
ZebrafishMelanomaRutheniumCancer researchChemistryCell biologyBiologyBiochemistryGeneCatalysisNanoplatforms for cancer theranosticsPhotochromic and Fluorescence ChemistryRetinal Development and Disorders