Taking regulatory T cells into medicine
Shimon Sakaguchi
Abstract
Regulatory T cells (Tregs) are indispensable for the establishment and maintenance of immunological self-tolerance. Their genetic anomalies or variations in function are causative of various monogenic and polygenic autoimmune diseases. Treg-based reestablishment of self-tolerance is envisioned to cure autoimmune diseases in the clinic.
Topics & Concepts
Self ToleranceImmunologyImmune toleranceFunction (biology)BiologyAutoimmunityAutoimmune diseaseRegulatory T cellMedicineGeneticsImmune systemT cellAntibodyIL-2 receptorT-cell and B-cell ImmunologyDiabetes and associated disordersImmune Cell Function and Interaction