Augmented expression of superoxide dismutase 2 mitigates progression and rupture of experimental abdominal aortic aneurysm
Huimin Yan, Ying Hu, Yang Lyu, Antonina Akk, Angela C. Hirbe, Samuel A. Wickline, Hua Pan, Elisha Roberson, Christine T. N. Pham
Abstract
These results confirm that SOD2 plays a pivotal role in the pathogenesis of experimental AAA and identify its potential as a therapeutic target.
Topics & Concepts
Superoxide dismutaseAbdominal aortic aneurysmMedicineAneurysmAortic aneurysmInternal medicinePathologyCardiologyRadiologyOxidative stressCardiac, Anesthesia and Surgical OutcomesAortic aneurysm repair treatmentsAortic Disease and Treatment Approaches