Chemical Protein Synthesis: Advances, Challenges, and Outlooks
Yi Tan, Hongxiang Wu, Tongyao Wei, Xuechen Li
Abstract
Contemporary chemical protein synthesis has been dramatically advanced over the past few decades, which has enabled chemists to reach the landscape of synthetic biomacromolecules. Chemical synthesis can produce synthetic proteins with precisely controlled structures which are difficult or impossible to obtain via gene expression systems. Herein, we summarize the key enabling ligation technologies, major strategic developments, and some selected representative applications of synthetic proteins and provide an outlook for future development.
Topics & Concepts
ChemistryNanotechnologySynthetic biologyComputational biologyChemical synthesisKey (lock)Biochemical engineeringBiochemistryEngineeringBiologyEcologyIn vitroMaterials scienceChemical Synthesis and AnalysisClick Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies Research