Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR
Monica G. Kamel, Farid M. Sroor, Mahmoud Kh. Hanafy, Karima F. Mahrous, Hamdi M. Hassaneen
Abstract
. The mechanism of action of compounds 4, 5 and 7 against pancreatic cancer cells was studied by investigating gene expression, DNA fragmentation, comet assay and flow cytometry experiments using doxorubicin as a reference drug. Moreover, the structure-activity relationship between the structures of these compounds and their biological properties was discussed.
Topics & Concepts
ThiazoleChalconePyrazoleChemistryCell cycle checkpointDNA fragmentationCell cycleCell cultureGeneStereochemistryCancer researchApoptosisBiochemistryBiologyProgrammed cell deathGeneticsSynthesis and biological activityCancer Mechanisms and TherapyCancer therapeutics and mechanisms