Relationship between Arterial Hypertension with Cognitive Performance in Elderly. Systematic Review and Meta-Analysis
José Miguel Sánchez-Nieto, Uriel Dagoberto Rivera-Sánchez, Vı́ctor Manuel Mendoza-Núñez
Abstract
BACKGROUND: Previous systematic reviews report that arterial hypertension (AHT) is associated with lower performance in cognition in the elderly. However, some studies show that with higher blood pressure, a better cognitive performance is obtained. OBJECTIVE: The aim of this study was to determine the relationship between AHT with cognitive performance in the elderly. METHODS: the review involved a search on PubMed, Scopus and PsycINFO databases from January 1990 to March, 2020 to identify the relationship among AHT and cognitive performance in older people. RESULTS: 1170 articles were identified, 136 complete papers were reviewed, a qualitative analysis of 26 studies and a quantitative analysis of eight studies were carried out. It was found that people with AHT have a lower performance in processing speed SMD = 0.40 (95% CI: 0.25, 0.54), working memory SMD = 0.28 (95% CI: 0.15, 0.41) in short-term memory and learning SMD = -0.27 (95% CI: -0.37, -0.17) and delayed recall SMD = -0.20 (95% CI: -0.35, -0.05). Only one study found that higher blood pressure was associated with better memory performance. CONCLUSION: Our results suggest that high blood pressure primarily affects processing speed, working memory, short-term memory and learning and delayed recall.