Emergence and Inter- and Intrahost Evolution of Pandrug-Resistant Klebsiella pneumoniae Coharboring <i>tmexCD1-toprJ1, bla</i> <sub>NDM-1</sub> , and <i>bla</i> <sub>KPC-2</sub>
Chao Liu, Pengcheng Du, Ping Yang, Jiajia Zheng, Juan Yi, Ming Lu, Ning Shen
Abstract
Pandrug-resistant (PDR) Klebsiella pneumoniae poses a great challenge to public health, and tigecycline is an essential choice for antimicrobial treatment. In this study, we reported the emergence of PDR K. pneumoniae coharboring tmexCD1-toprJ1 , bla NDM-1 , and bla KPC-2 , which belongs to ST22 and ST3691.
Topics & Concepts
Klebsiella pneumoniaeTigecyclineBiologyKlebsiella infectionsMicrobiologyAntimicrobialGeneticsGeneEscherichia coliAntibiotic Resistance in BacteriaCancer therapeutics and mechanismsBacterial biofilms and quorum sensing