Continuous organocatalytic flow synthesis of 2-substituted oxazolidinones using carbon dioxide
Nicola Zanda, Leijie Zhou, Esther Alza, Arjan W. Kleij, Miquel À. Pericàs
Abstract
A catalytic continuous flow approach towards pharmaceutically relevant oxazolidinones has been developed using epoxy alcohols and CO 2 as reagents, taking advantage of a stable, scalable and metal- and halide-free protocol.
Topics & Concepts
ReagentHalideContinuous flowCatalysisChemistryFlow chemistryCombinatorial chemistryCarbon dioxideOrganocatalysisOrganic chemistryEnantioselective synthesisBiochemical engineeringEngineeringCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisCatalysis for Biomass Conversion