Rh(III)‐Catalyzed Direct <i>ortho</i> Alkylation of Carbazoles with Nitroalkenes
Liming Zhang, Ru Zhao, Chunhui Liu, Zhao‐Yang Li, Jun‐Long Niu, Haoran Yang, Lijun Gao, Shuang‐Liang Liu, Liming Zhou
Abstract
Abstract The Rh(III)‐catalyzed ortho alkylation of N ‐pyridylcarbazoles with nitroalkenes has been developed, furnishing a wide range of 2‐(2‐nitroalkyl)carbazoles. Both aromatic and aliphatic nitroalkenes participated in this alkylation reaction successfully. This protocol also proceeded well with an indoline based substrate. Derivatization of the representative nitroalkane product was described.
Topics & Concepts
ChemistryAlkylationIndolineCatalysisDerivatizationOrganic chemistrySubstrate (aquarium)Medicinal chemistryHigh-performance liquid chromatographyGeologyOceanographyCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCatalytic Cross-Coupling Reactions