Alfalfa saponins inhibit oxidative stress-induced cell apoptosis through the MAPK signaling pathway
Yalei Cui, Fen Li, Xiaoyan Zhu, Junying Xu, Muhammad Abaidullah, Yanyan Chen, Defeng Li, Boshuai Liu, Chengzhang Wang, Zhichang Wang, Sen Ma, Xule Liu, Yinghua Shi
Abstract
BACKGROUND: . METHODS: -induced oxidative cell damage was explored by detecting the expression of mitochondrial apoptosis-related proteins. Furthermore, the signaling pathway of alfalfa saponins in IPEC-J2 cells under oxidative stress was also investigated. RESULTS: -induced cells. CONCLUSION: Alfalfa saponins could inhibit oxidative stress-induced cell mitochondrial apoptosis through the MAPK signaling pathway, thereby providing a new method for improving antioxidant stress ability by means of nutritional regulation.
Topics & Concepts
Oxidative stressApoptosisViability assayAntioxidantMAPK/ERK pathwaySignal transductionMedicago sativaOxidative phosphorylationReactive oxygen speciesCell biologyCellChemistryCell growthBiologyBiochemistryBotanyBiochemical effects in animalsNatural product bioactivities and synthesisPharmacological Effects of Natural Compounds