Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome
Kaiming Zhang, Ivan N. Zheludev, Rachel J. Hagey, Raphael Haslecker, Yixuan J. Hou, Rachael C. Kretsch, Grigore Pintilie, Ramya Rangan, Wipapat Kladwang, Shanshan Li, Marie Teng-Pei Wu, Edward A. Pham, Claire Bernardin-Souibgui, Ralph S. Baric, Timothy P. Sheahan, Victoria D′Souza, Jeffrey S. Glenn, Wah Chiu, Rhiju Das
Topics & Concepts
Frameshift mutationRNAVirologyGenomeAntisense RNABiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)DNA Transposable ElementsCoronavirus disease 2019 (COVID-19)GeneticsMolecular biologyComputational biologyCell biologyGeneMedicineMutationDiseasePathologyTransposable elementInfectious disease (medical specialty)Bacteriophages and microbial interactionsAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanisms