Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis
Zhendong Song, Yi‐You Huang, Ke‐Qiang Hou, Lu Liu, Feng Zhou, Yue Huang, Guohui Wan, Hai‐Bin Luo, Xiao‐Feng Xiong
Abstract
exhibited remarkable therapeutic effects in an imiquimod-induced psoriasis mouse model.
Topics & Concepts
PsoriasisChemistryPotencyDruggabilityPharmacologyDrugImiquimodIn vitroBiochemistryDermatologyMedicineGeneMast cells and histaminePhosphodiesterase function and regulationAsthma and respiratory diseases