PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
Jianfeng Wang, Chen Wang, Pan Xu, Xiao Li, Yongning Lu, Di Jin, Xiaomao Yin, Hao Jiang, Jing Huang, Huan Xiong, Fei Ye, Jia Jin, Yu Chen, Yiqian Xie, Zhifeng Chen, Hong Ding, Hao Zhang, Rongfeng Liu, Hualiang Jiang, Kaixian Chen, Zhiyi Yao, Cheng Luo, Huang Yi-ran, Yuanyuan Zhang, Jin Zhang
Abstract
Taken together, our study revealed a PRMT1-dependent epigenetic mechanism in the control of ccRCC tumor growth and drug resistance, indicating PRMT1 may serve as a promising target for therapeutic intervention in ccRCC patients.
Topics & Concepts
Clear cell renal cell carcinomaCancer researchCell growthBiologyGene knockdownCarcinogenesisCell cycleDownregulation and upregulationEpigeneticsCell cycle checkpointProtein kinase BPI3K/AKT/mTOR pathwayCellCancerSignal transductionCell cultureCell biologyMedicineRenal cell carcinomaInternal medicineGeneticsGeneBiochemistryCancer-related gene regulationRenal and related cancersEpigenetics and DNA Methylation