Electrophilic Halospirocyclization of <i>N</i>-Benzylacrylamides to Access 4-Halomethyl-2-azaspiro[4.5]decanes
Zhongyi Zhang, Wei Zhang, Zhong‐Wei Hou, Pinhua Li, Lei Wang
Abstract
-halosuccinimides (NXS) as the halogenating reagents has been developed. This reaction is carried out at room temperature under simple conditions without relying on metal reagents, photochemistry, or electrochemistry, providing a fast and efficient route to synthesize a wide variety of 4-halomethyl-2-azaspiro[4.5]decanes with satisfactory yields. The approach is further highlighted through gram-scale synthesis and diverse transformations of the spiro products.
Topics & Concepts
ElectrophileReagentChemistryCombinatorial chemistryVariety (cybernetics)ElectrochemistryScale (ratio)Computer scienceOrganic chemistryCatalysisPhysicsArtificial intelligencePhysical chemistryQuantum mechanicsElectrodeOxidative Organic Chemistry ReactionsRadical Photochemical ReactionsCatalytic C–H Functionalization Methods