Cocrystallization of 5-fluorouracil and <scp>l</scp>-phenylalanine: the first zwitterionic cocrystal of 5-fluorouracil with amino acid exhibiting perfect <i>in vitro</i>/<i>vivo</i> pharmaceutical properties
Lin‐Lin Wang, Ling‐Yang Wang, Yue‐Ming Yu, Yan‐Tuan Li, Zhi‐Yong Wu, Cui‐Wei Yan
Abstract
The first zwitterionic cocrystal of 5-fluorouracil with amino acid has been prepared and its structure and <italic>in vitro</italic>/<italic>vivo</italic> properties have been systematically studied.
Topics & Concepts
CocrystalFluorouracilIn vivoPhenylalanineIn vitroChemistryAmino acidStereochemistryBiochemistryMoleculeOrganic chemistryBiologyHydrogen bondChemotherapyGeneticsBiotechnologyCrystallography and molecular interactionsEnzyme Structure and FunctionCrystallization and Solubility Studies