Novel Prostate Cancer Biomarkers: Aetiology, Clinical Performance and Sensing Applications
Tomáš Bertók, Anikó Bertóková, Štefánia Hrončeková, Erika Chocholova, Natalia Svecova, Lenka Lorencová, Peter Kasák, Jan Tkáč
Abstract
The review initially provides a short introduction to prostate cancer (PCa) incidence, mortality, and diagnostics. Next, the need for novel biomarkers for PCa diagnostics is briefly discussed. The core of the review provides details about PCa aetiology, alternative biomarkers available for PCa diagnostics besides prostate specific antigen and their biosensing. In particular, low molecular mass biomolecules (ions and metabolites) and high molecular mass biomolecules (proteins, RNA, DNA, glycoproteins, enzymes) are discussed, along with clinical performance parameters.
Topics & Concepts
Prostate cancerBiomoleculeCancer biomarkersProstate-specific antigenMolecular diagnosticsComputational biologyCancerMedicineBioinformaticsNanotechnologyBiologyInternal medicineMaterials scienceMetabolomics and Mass Spectrometry StudiesMass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications