Prevalence of Pathogenic Variants in Cancer Susceptibility Genes Among Women With Postmenopausal Breast Cancer
Allison W. Kurian, Ryan Bernhisel, Katie Larson, Jennifer L. Caswell‐Jin, Aladdin H. Shadyab, Heather M. Ochs‐Balcom, Marcia L. Stefanick
Abstract
This study uses Women’s Health Initiative data to compare the prevalence of pathogenic variants (PVs) in breast cancer susceptibility genes in postmenopausal women with vs without breast cancer to guide decisions about who should undergo PV testing.
Topics & Concepts
MedicineBreast cancerPostmenopausal womenCancerGeneOncologyInternal medicineGynecologyGeneticsBiologyBRCA gene mutations in cancerDNA Repair Mechanisms