Supramolecular intermediates in thermo-mechanochemical direct amidations
Tomislav Stolar, Jasna Alić, Gregor Talajić, Nikola Cindro, Mirta Rubčić, Krešimir Molčanov, Krunoslav Užarević, José G. Hernández
Abstract
monitoring methods led to the observation, isolation, and characterisation of multicomponent crystalline intermediates that precede the formation of amides. We applied our methodology for the quantitative synthesis of the active pharmaceutical ingredient moclobemide.
Topics & Concepts
Covalent bondSupramolecular chemistryReagentAmideMechanochemistryChemistryPeptide bondSolventCombinatorial chemistryCoupling (piping)Organic chemistryMaterials scienceMoleculeEnzymeMetallurgyCrystallography and molecular interactionsAdvanced Synthetic Organic ChemistryChemical Synthesis and Analysis