Extracellular histones promote TWIK2-dependent potassium efflux and associated NLRP3 activation in alveolar macrophages during sepsis-induced lung injury
Jing Yu, Yu Fu, Nan Zhang, Jiameng Gao, Zhiyuan Zhang, Xuemei Jiang, Chang Chen, Zongmei Wen
Topics & Concepts
ExtracellularInflammasomeDownregulation and upregulationInflammationCell biologyBronchoalveolar lavageChemistryNeutrophil extracellular trapsHistoneIntracellularImmunologyBiologyLungMedicineBiochemistryInternal medicineGeneNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammasome and immune disordersImmune cells in cancer