Intracellular S. aureus in Osteoblasts in a Clinical Sample from a Patient with Chronic Osteomyelitis—A Case Report
Nike Walter, Daniel H. Mendelsohn, Christoph Brochhausen, Markus Rupp, Volker Alt
Abstract
The pathophysiological role of intracellular bacteria in osteomyelitis is still a matter of debate. Here, we demonstrate for the first time the presence of Staphylococcus aureus internalized into osteoblasts in human tissue samples of a case with a chronic osteomyelitis using ultrastructural transmission electron microscope analysis.
Topics & Concepts
Staphylococcus aureusOsteomyelitisIntracellularPathophysiologyMicrobiologyUltrastructureBacteriaTransmission electron microscopyIntracellular parasiteMedicineChemistryPathologyBiologyImmunologyCell biologyMaterials scienceNanotechnologyGeneticsOrthopedic Infections and TreatmentsInfective Endocarditis Diagnosis and ManagementAntimicrobial Resistance in Staphylococcus