Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Jason Reeves, Rahul Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi, Denis Schapiro, Prajan Divakar, Eric Miller, Daniel R. Zollinger, George Eng, Jason M. Schenkel, Jennifer Su, Carina Shiau, Patrick Yu, William A. Freed-Pastor, Domenic Abbondanza, Arnav Mehta, Joshua Gould, Conner Lambden, Caroline Porter, Alexander M. Tsankov, Danielle Dionne, Julia Waldman, Michael S. Cuoco, Lan Nguyễn, Toni Delorey, Devan Phillips, Jaimie L. Barth, Marina Kem, Clifton Rodrigues, Debora Ciprani, Jorge Roldán, Piotr Zelga, Vjola Jorgji, Jonathan Chen, Zackery A. Ely, Daniel Zhao, Kit Fuhrman, Robin Fropf, Joseph Beechem, Jay S. Loeffler, David P. Ryan, Colin D. Weekes, Cristina R. Ferrone, Motaz Qadan, Martin J. Aryee, Rakesh K. Jain, Donna Neuberg, Jennifer Y. Wo, Theodore S. Hong, Ramnik J. Xavier, Andrew J. Aguirre, Orit Rozenblatt–Rosen, Mari Mino–Kenudson, Carlos Fernández‐del Castillo, Andrew S. Liss, David T. Ting, Tyler Jacks, Aviv Regev