Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory
Shu K. E. Tam, Laurence A. Brown, Tatiana S. Wilson, Selma Tir, Angus S. Fisk, Carina A. Pothecary, Vincent van der Vinne, F. Foster, Vladyslav V. Vyazovskiy, David M. Bannerman, Mary E. Harrington, Stuart N. Peirson
Abstract
mice, indicating that rods and cones are capable of driving these responses in the absence of melanopsin. DLE delays molecular clock rhythms in the heart, liver, adrenal gland, and dorsal hippocampus. It also reverses short-term recognition memory performance, which is associated with changes in preceding sleep history. In addition, DLE modifies patterns of hypothalamic and cortical cFos signals, a molecular correlate of recent neuronal activity. Together, our data show that DLE causes coordinated realignment of circadian rhythms, sleep patterns, and short-term memory process in mice. These effects are particularly relevant as DLE conditions-due to artificial light exposure-are experienced by the majority of the populace on a daily basis.