Sudden Cardiac Arrest in a Patient With Mitral Valve Prolapse and LMNA and SCN5A Mutations
Asha M. Mahajan, Yuval Itan, Marina Cerrone, James M. Horowitz, Linda Borneman, Larry A. Chinitz, Lior Jankelson
Abstract
Bileaflet mitral valve prolapse (Bi-MVP) is associated with increased risk for cardiac arrest. We describe a patient who presented after a cardiac arrest with Bi-MVP and variants in Lamin A/C (LMNA) and the sodium channel alpha-subunit 5a (SCN5A). Genetic variants may be the culprit for arrhythmogenesis in Bi-MVP patients. (Level of Difficulty: Intermediate.)
Topics & Concepts
LMNACardiologySudden cardiac arrestInternal medicineMedicineCulpritMitral valve prolapseSudden cardiac deathMitral valveLaminMyocardial infarctionPsychiatryNucleusNuclear Structure and FunctionGenomics and Rare DiseasesNeurogenetic and Muscular Disorders Research