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Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells

Delu Dong, Yuan Dong, Jiaying Fu, Shengyao Lu, Chunli Yuan, Meihui Xia, Liankun Sun

2020Life Sciences32 citationsDOI

Topics & Concepts

Warburg effectApoptosisCancer cellOxidative stressViability assayGLUT1PKM2Anaerobic glycolysisGlucose uptakeBiologyGlycolysisCancer researchChemistryCell biologyCancerBiochemistryEndocrinologyMetabolismInsulinPyruvate kinaseGeneticsCell death mechanisms and regulationCancer, Hypoxia, and MetabolismATP Synthase and ATPases Research
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells | Litcius