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Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway

Rongzhen Deng, Yuping Zhu, Keli Liu, Qun Zhang, Shaofan Hu, Meng Wang, Yiguo Zhang, Yiguo Zhang

2024Bioorganic Chemistry15 citationsDOI

Topics & Concepts

Pentose phosphate pathwayPI3K/AKT/mTOR pathwayNRF1ChemistryCell biologyProtein kinase BBiochemistryGluconeogenesisMetabolic pathwaymTORC1GlycolysisBiologySignal transductionMetabolismMitochondrionMitochondrial biogenesisCancer, Hypoxia, and MetabolismGenomics, phytochemicals, and oxidative stressMitochondrial Function and Pathology
Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway | Litcius