Targeting cancer’s sweet spot: UGP2 as a therapeutic vulnerability
Sung-Hoon Kim, Sunghoon Kim, Andrew L. Wolfe, Sung Eun Kim, Sung Eun Kim
Abstract
Understanding the mechanisms governing metabolic reprogramming that underlie potential vulnerabilities in cancer cells is key to developing novel therapeutic strategies. The catalytic enzyme UDP-glucose pyrophosphorylase 2 (UGP2) drives the production of UDP-glucose. Our recent work demonstrated the crucial role of UGP2 in cancer growth and its regulation of cellular metabolic processes.
Topics & Concepts
ReprogrammingSweet spotCancerCancer cellBiologyVulnerability (computing)Key (lock)EnzymeCancer researchCell biologyBiochemistryCellGeneticsComputer scienceEcologyPaleontologyComputer securityShear (geology)Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerMitochondrial Function and Pathology