FSTL1 promotes growth and metastasis in gastric cancer by activating AKT related pathway and predicts poor survival.
Mengjie Wu, Yongfeng Ding, Nan Wu, Junjie Jiang, Yingying Huang, Fanyu Zhang, Haiyong Wang, Quan Zhou, Yan Yang, Wei Zhuo, Lisong Teng
Abstract
. Furthermore, we demonstrate that FSTL1 is involved in regulation of the AKT signaling through analyzing databases and experimental results. Mechanistic studies showed that FSTL1 promoted proliferation, migration and invasion in GC, at least partially, by activating AKT via regulating TLR4/CD14. In all, this study highlights the role of the FSTL1-TLR4/CD14-AKT axis, which provided novel insights into the mechanism of growth and metastasis in GC for the first time.
Topics & Concepts
Protein kinase BCancer researchMetastasisCarcinogenesisCancerDownregulation and upregulationApoptosisCell growthBiologyMedicineSignal transductionInternal medicineCell biologyGeneBiochemistryGeneticsTGF-β signaling in diseasesCancer, Lipids, and MetabolismKruppel-like factors research