Discovery of new indole-based 1,2,4-triazole derivatives as potent tubulin polymerization inhibitors with anticancer activity
Fang Yang, Xie‐Er Jian, Lin Chen, Yufeng Ma, Yuxia Liu, Wen‐Wei You, Pei‐Liang Zhao
Abstract
Thirty-six novel indole-based 1,2,4-triazole derivatives were designed and synthesized through the molecular hybrid strategy.
Topics & Concepts
ChemistryIndole testTubulinTriazoleCombinatorial chemistryPolymerizationMicrotubuleStereochemistryOrganic chemistryCell biologyPolymerBiologyClick Chemistry and ApplicationsSynthesis and biological activitySynthesis and Biological Evaluation