Dietary phytochemicals alleviate the premature skin aging: A comprehensive review

Abstract

Skin aging, often called as premature skin aging, is the hastened deterioration of the skin resulting from multiple factors, including UV radiation, environmental contaminants, inadequate nutrition, stress, etc. Dietary phytochemicals, present in fruits, vegetables, and other plant-derived meals, have gained interest due to their efficiency to eradicate free radicals and lowering the release of inflammatory mediators which accounts for premature skin aging. Several dietary phytochemicals, i.e. , carotenoids, polyphenols, flavonoids, terpenes, alkaloids, phytosterols, etc. , exhibited potential anti-oxidant, anti-inflammatory, suppression of UV damage, and promote collagen synthesis. In addition, dietary phytochemicals include sulfur, present in various foods safeguard the skin against oxidative stress and inflammation. Thus, this article delves into the comprehension of various dietary phytochemicals investigated to alleviate the premature skin aging. The article further highlights specific phytochemicals and their sources, bioavailability, mechanisms, etc. , in the context of safeguarding the skin against oxidative stress and inflammation. The present manuscript is a systematic comprehension of the available literature on dietary phytochemicals and skin aging in various database, i.e. , PubMed, ScienceDirect, Google Scholar using the keywords, i.e. , “dietary phytochemicals”, “nutraceuticals”, “skin aging” etc. , via Boolean operator, i.e. , “AND”. The dietary guidelines presented in the manuscript is a unique summarization for a broad reader to understand the inclusion of various functional foods, nutrients, supplements, etc. , to prevent premature skin aging. Thus, the utilization of dietary phytochemicals has shown a promising avenue in preventing skin aging, however, the future perspectives and challenges of such phytochemicals should be comprehended via clinical investigations. • Systematically presents data on dietary phytochemicals and premature skin aging from 1995 to 2024. • Comprehensive literature search across multiple databases (PubMed, Scopus, ScienceDirect, Springer, Taylor & Francis). • Inclusion criteria: Dietary phytochemicals, skin anti-aging, preclinical and clinical trials on pharmacological evaluation. The studies on antiaging having n = 6 were included. • Exclusion criteria: Nonavailability of full text of manuscript and in languages other than English were excluded in the review. • Emphasizes the significance of phytochemicals found in fruits, vegetables, and plant-based meals in neutralizing free radicals and reducing inflammatory mediators linked to premature aging of skin.

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