Transition Metal Catalyzed Hiyama Cross-Coupling: Recent Methodology Developments and Synthetic Applications
Rida Noor, Ameer Fawad Zahoor, Muhammad Irfan, Syed Makhdoom Hussain, Sajjad Ahmad, Ali Irfan, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Abstract
Hiyama cross-coupling is a versatile reaction in synthetic organic chemistry for the construction of carbon-carbon bonds. It involves the coupling of organosilicons with organic halides using transition metal catalysts in good yields and high enantioselectivities. In recent years, hectic progress has been made by researchers toward the synthesis of diversified natural products and pharmaceutical drugs using the Hiyama coupling reaction. This review emphasizes the recent synthetic developments and applications of Hiyama cross-coupling.
Topics & Concepts
Coupling reactionChemistryCatalysisHalideOrganic synthesisTransition metalCombinatorial chemistryOrganic chemistryCarbon fibersCoupling (piping)NanotechnologyMaterials scienceMetallurgyComposite materialComposite numberCatalytic Cross-Coupling ReactionsChemical synthesis and alkaloidsCatalytic C–H Functionalization Methods