EDA Complex-Enabled Annulation to Access CF<sub>2</sub>-Containing Tetralones and Quinazolinones Using Persulfates as Electron Donors
Shupeng Zhang, Dawei Guo, Mei-Ling Yang, Yun‐Tao Xia, Wenchao Yang
Abstract
A photocatalyst-free and EDA complex-enabled radical cascade cyclization reaction of inactive alkenes with bromodifluoroacetamides was reported for the divergent synthesis of fluorine-containing tetralones and quinazolinones. In this transformation, persulfates as electron donors and difluoro bromamide as electron acceptors generate the EDA complex. This is a promising photochemical method with advantages such as mild reaction conditions, simple operation, being metal-free, and excellent functional group tolerance.
Topics & Concepts
TetralonesAnnulationChemistryCombinatorial chemistryCascadePhotochemistryMedicinal chemistryOrganic chemistryCatalysisChromatographyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques