Signaling through Syk or CARD9 Mediates Species-Specific Anti-<i>Candida</i>Protection in Bone Marrow Chimeric Mice
Erik Zajta, Katalin Csonka, Adél Tóth, László Tiszlavicz, Tamás Németh, Anita Orosz, Ádám Novák, M. Csíkos, Csaba Vágvölgyi, Attila Mócsai, Attila Gácser
Abstract
While C. albicans remains the most clinically significant Candida species, C. parapsilosis is an emerging pathogen with increased affinity to neonates. Syk/CARD9 signaling is crucial in immunity to C. albicans , but its role in in vivo responses to other pathogenic Candida species is largely unexplored.
Topics & Concepts
SykCandida albicansIn vivoCorpus albicansMicrobiologyCandida parapsilosisImmunityPathogenBone marrowBiologyFungal pathogenSignal transductionImmunologyCell biologyImmune systemTyrosine kinaseGeneticsAntifungal resistance and susceptibilityFungal Infections and StudiesCystic Fibrosis Research Advances