Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions
Kamal Krishna Rajbongshi, Srinivas Ambala, Thavendran Govender, Hendrik G. Kruger, Per I. Arvidsson, Tricia Naicker
Abstract
An efficient catalyst-free radical cross-coupling reaction between aromatic aldehydes and sulfoximines was developed. The reaction took place in the presence of N-bromosuccinimide as the radical initiator under microwave irradiation to afford the corresponding acylated sulfoximines in moderate to excellent yields (27 examples). This protocol proved to be rapid, easy to handle, and applicable to a broad scope of substrates.
Topics & Concepts
ChemistryAcylationCatalysisMicrowave irradiationOrganic chemistryRadicalMicrowaveScope (computer science)Combinatorial chemistryAldehydeComputer sciencePhysicsQuantum mechanicsProgramming languageSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques