BRAFV 600E or mutant MAP2K1 human CD34+ cells establish Langerhans cell–like histiocytosis in immune-deficient mice
Anahita Rafiei, C. Matthias Wilk, Patrick M. Helbling, Renier Myburgh, Yasuyuki Saito, Eugenia Haralambieva, Davide Soldini, Rikhia Chakraborty, Miriam Mérad, Carl E. Allen, César Nombela‐Arrieta, Markus G. Manz
Abstract
Key Points BRAFV600E or mutant MAP2K1 expression in human CB CD34+ HSPCs lead to Langerhans cell–like histiocytosis in immune-deficient mice. BRAFV600E-expressing human CB CD34+ HSPCs did not generate hairy cell leukemia in xenograft mouse models.
Topics & Concepts
Langerhans cell histiocytosisCD34Immune systemProgenitor cellMutantBiologyCancer researchImmunologyHistiocytosisCell biologyStem cellInternal medicineMedicineGeneDiseaseBiochemistryHistiocytic Disorders and TreatmentsViral-associated cancers and disordersImmunotherapy and Immune Responses