Aqueous Micellar Environment Impacts the Co-Catalyzed Phototransformation: A Case Study
Aleksandra Wincenciuk, Piotr Cmoch, Maciej Giedyk, Martin Andersson, Dorota Gryko
Abstract
High Resolution Image Download MS PowerPoint Slide In recent years, methodologies that rely on water as the reaction medium have gained considerable attention. The unique properties of micellar solutions were shown to improve the regio-, stereo-, and chemoselectivity of different transformations. Herein, we demonstrate that the aqueous environment is a suitable medium for a visible light driven cobalt-catalyzed reaction involving radical species. In this system, reduced vitamin B 12 reacts with alkyl halides, generating radicals that are trapped by the lipophilic olefin present in the Stern layer. A series of NMR measurements and theoretical studies revealed the location of reaction components in the micellar system.