Whole-Genome Methylation Sequencing Reveals that COVID-19–induced Epigenetic Dysregulation Remains 1 Year after Hospital Discharge
Joseph Balnis, Andy Madrid, Kirk J. Hogan, Lisa A. Drake, Anish Adhikari, Rachel Vancavage, Harold A. Singer, Reid S. Alisch, Ariel Jaitovich
Abstract
growth and mobilization of wild-type and mutated cells, leading to the formation of hamartomas or benign tumors (Figure 1E).LAM cells in the lung and circulation can increase the production of CD44v6 regulators (OPN, HGF, SDF-1 or CXCL12).The production of these growth factors can be potentiated on the basis of the genotype of each patient.The fact that CD44v6 is a coreceptor of HGF supports a positive paracrine and autocrine feedback mechanism of action of the microenvironment by increasing the concentrations of HGF and increasing the splicing of CD44 to generate CD44v6 and potentiating LAM cell growth.Therefore, neoplastic LAM cells appear to interact with and require the cells of the microenvironment (e.g., macrophages, neutrophils) to form nodules or "microtumors.