Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice
Qi Fu, Hemin Jiang, Yu Qian, Hui Lv, Hao Dai, Yuncai Zhou, Yang Chen, Yunqiang He, Rui Gao, Shuai Zheng, Yucheng Liang, Siqi Li, Xinyu Xu, Kuanfeng Xu, Tao Yang
Topics & Concepts
BiologyCellAlpha cellProteomicsDownregulation and upregulationCell typeFlow cytometryCell biologyIsletMolecular biologyBeta cellEndocrinologyGeneDiabetes mellitusGeneticsPancreatic function and diabetesSingle-cell and spatial transcriptomicsDiabetes and associated disorders